GLP-1 Receptor Agonists for Weight Loss in People without Type …
WEBMay 12, 2023 · The evidence supporting the use of GLP-1 RAs for weight loss in nondiabetic individuals is still evolving, and our knowledge is more limited compared to the benefits in patients with type 2 diabetes.
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes
WEBNov 11, 2023 · Semaglutide, a long-acting analogue of GLP-1, administered at a dose of 2.4 mg subcutaneously once weekly for 104 weeks, was found to reduce body weight by a mean of 15.2% among patients with...
Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive …
WEBJun 21, 2023 · GLP-1 agonists, used to treat type 2 diabetes, have been shown to be effective in promoting weight loss in preclinical and clinical studies. This review summarizes numerous studies conducted on the main drugs in the GLP-1 agonists class, outlining the maximum achievable weight loss.
Efficacy of GLP-1 Agonists for Weight Loss in Adults Without Diabetes
WEBJun 16, 2022 · The new indications include weight loss in adults with obesity (body mass index [BMI] ≥30) without diabetes and adults with a BMI ≥27 and 1 weight-related comorbidity (hypertension, type 2 ...
A Balancing Act: GLP-1 Receptor Agonists for Non-Diabetic Obesity
WEBDec 29, 2020 · GLP-1 agonists are a promising drug class originally developed for the treatment of type 2 diabetes, but recently shown to be effective for weight loss in non-diabetic patients with obesity or overweight BMI when given as adjunctive therapy to diet and exercise. 8 Endogenous glucagon-like peptide-1 (GLP-1) is …
Efficacy of GLP-1 RA Approved for Weight Management in …
WEBMay 3, 2022 · The mean weight loss difference between GLP-1 RAs and placebo as add-on to lifestyle intervention in patients with diabetes was 4% to 6.2% compared to 6.1 to 17.4% in people without diabetes. Semaglutide compared to …
The Weight-loss Effect of GLP-1RAs Glucagon-Like Peptide-1 …
WEBThe present study provides conclusive evidence for the effect of GLP-1RAs on weight loss in a nonlinear dose-response manner in patients with obesity or overweight without diabetes. In terms of changes in BW, BMI, and WC, there is firm evidence for the overall weight-loss effects of GLP-1RAs.
Efficacy of Glucagon-Like Peptide 1 (GLP-1) Receptor Agonists for ...
WEBJul 21, 2024 · This review aims to discuss the efficacy of the diabetic pharmacologic agents, glucagon-like peptide-1 (GLP-1) receptor agonists, on body weight. The review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines 2020 and includes a comprehensive search strategy.
GLP-1 receptor agonists effective for weight loss in obesity …
WEBMay 29, 2024 · Researchers employed benefit-harm balance modeling to assess the effects of GLP-1 RAs on weight loss in adults without diabetes.
GLP-1 Receptor Agonists for Weight Loss in People without Type …
WEBGLP-1 Receptor Agonists for Weight Loss in People without Type 2 Diabetes: What is the Current Evidence? Am J Clin Nutr. 2023 Sep;118 (3):494-495. doi: 10.1016/j.ajcnut.2023.07.007. Epub 2023 Aug 8. Author. Lise Lotte Gluud 1. Affiliation. 1 Gastro Unit, Copenhagen University Hospital Hvidovre, Hvidovre 2650, Denmark.